Eleusis SPAC
ELE-Psilo PK/PD Simulations
Plasma psilocin concentration (µg/L)
(Predicted)
IV administration could rapidly reach target intensity and rapidly return below perceptual threshold
100
10
0.1
eleusis
Psilocin Concentration-Time Profile (Simulated)
(10 and 20-minute IV Psilocin vs Oral 25 mg of Psilocybin)
0
www.
10
20
30 40 50
Time (min)
60
2 mg IV Psilocin; 10 min infusion
4 mg IV Psilocin; 20 min infusion
25 mg PO; Psilocybin
Estimated PD Threshold
5-HT2A Receptor Occupancy
Target Range
Eleusis simulations suggest
target concentrations of
psilocin reachable in ~2 min
Simulations also support
potential personalization of
intensity via alteration of
infusion rate
Source: 1) Hasler, F. et al. (1997). Determination of psilocin and 4-hydroxyindole-3-acetic acid in plasma by HPLC-ECD and pharmacokinetic profiles of oral and intravenous psilocybin in man. Pharmaceutica Acta Helvetiae,
72(3), 175-184;
Eleusis simulations based on primary data from Brown et al. 2017, Madsen et al. 2019, Hasler et al. 1997, and Carhart-Harris et al. 2011.
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