Investor Presentation

17X Lenabasum Safety Overview HAS ACCEPTABLE SAFETY PROFILE AND IS WELL-TOLERATED BASED ON DATA TO-DATE • No serious or severe lenabasum-related AEs to-date Maximum Tolerated Dose: 180 mg total daily dose Dose limiting toxicity = Multiple mild to moderate AEs occurred in a given subject, e.g., dizziness, fatigue, nausea, vomiting, feeling odd, and orthostatic hypotension ● Lenabasum AEs in ≥ 2% of 160 subjects treated with lenabasum at therapeutic doses ≤ 60 mg/day are consistent with low level CB1 agonist activity of lenabasum Dizziness 5% Fatigue - 2.5% - Changes from baseline in vital signs and laboratory safety tests not different from placebo

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