Omega Therapeutics IPO Presentation Deck

In vivo Control of Master Regulator Translation across species demonstrated for OEC candidate in healthy liver tissues through increase in HNF4a expression Species Liver Cells Relative expression (%) 500- 400- 300- 200 100- Ⓒ2021 Omega Therapeutics, Inc. Mouse Mouse (48h) Negative control 4 OEC Candidate Relative expression (%) 250- 200- 150- 100- 50- Nonhuman primate Nonhuman primate (24h) Negative control *Significant, paired 1-test p<0.05 OEC Candidate Relative expression (%) 150- 100- 50- FRG Mouse Human (24h) Negative control OEC Candidate 25

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