Investor Presentaiton

Smart Liquid Biopsy will continue to unlock the rich landscape of blood-based markers INVESTOR 20 DAY 23 micro-vesicles exomeres NETS immune cells apoptotic bodies TEPS microbiome genome-wide fragmentation chromatin organization fragments ending point mutations topology exosomes epigenetic alterations copy number aberrations proteins CpG sites Microenvironmental Epigenetic and immune features influence GUARDANT™ Adapted from Van der Pol., Cancer Cell, 2019 rearrangements virome TLR receptors TFs nucleosomal occupancy mtDNA Blood Sample Genomic features Tumor-Specific | Derived targets 44

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