Investor Presentaiton

129 Investor presentation Full year 2022 Insulin market size and volume market share in Rest of World Insulin market share and market size (DKK billion) Total 42% Long- acting 63% Fast- 2 acting Premix 83% 2 Human 66% 2 58% 5 Novo Nordisk Competitors Rest of World Market growth A Market share Insulin volume: Market share 80% 20% 12 7.7% +1.2% 60% 15% 57% 10% 10.3% +1.9% 40% 5% 5.7% +0.8% 20% 7.0% +1.3% 0% Nov 2019 5.0% +0.9% -NN market share Source: IQVIA, Nov 2022; LHS graph - Value, RHS Graph - Volume, MAT; Share of growth not depicted due to too high numbers; NN: Novo Nordisk 0% -4% -5% -5% -10% Nov 2022 -Market growth (right axis) -NN growth (right axis)

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