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Investor Presentaiton

Company overview Financial review 2022 priorities Appendix References 1 GROWTH Strong Kesimpta®Ⓡ launch continues, outperforming market CEZ K Kesimpta L Sales evolution USD m, % cc Ex-US US 99 66 50 147 109 +24% 239 195 Q1/21 Q2/21 Q3/21 Q4/21 Q1/22 Q2/22 Launch acceleration continues Increasing real-world experience with >20k patients treated WW US demand +18% QoQ, >3,200 adopters since launch NBRX +42% YoY vs. US NBRx market -12%1 Strengthening differentiation and benefit/risk profile New extension phase data: 8/10 patients treated continuously with KesimptaⓇ had no evidence of disease activity (NEDA-3)² Fast initiation within 6 days for 80% patients³ 77% of patients remain on therapy at 12 months4 See last slide for references WW-worldwide NBRX - New to brand Prescription NEDA - No Evidence of Disease Activity 12 Investor Relations | Q2 2022 Results NOVARTIS | Reimagining Medicine
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