Investor Presentaiton
Estetrol: unique mode of action vs other estrogens
AGONIST on
the nuclear ERa
Activates the nuclear
estrogen receptor²-4
Important estrogenic
activity on the
vagina, endometrium,
bone and
cardiovascular system
to provide beneficial
effects²-4
BRO &Ro
www
ESTROGENS
ESTETROL
&Ro
Membrane
•
.
ANTAGONIST on
the membrane ERa
Blocks the membrane
estrogen receptor²-4
Neutral effect on the
liver unlike other
estrogens²-4
Low impact on breast
tissue (normal and
malignant) 5-8
1. Abot A et al. EMBO Mol Med 2014.2.Foidart JM et al. InL Brinton RD et al (eds) 2019, Sex Steroids Effects on Brain, Heart and Vessels. ISGE Series.3.Arnal JF et
al. Physiol Rev 2017. 4.Giretti MS et al. Front Endocrinol, 2014.5.Gerard C et al Endocrinol 2015. 6.Singer CF et al. Carcinogenesis, 2014. 7.Visser M et al. Horm Mol Biol
Clin Invest 2012.
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