Unlocking Hope for Cancer Patients Using PDT
7
POTENTIAL TO ACTIVATE AN IMMUNE RESPONSE
PROTECTIVE IMMUNITY AND ABSCOPAL EFFECT
"PDT has the potential to eliminate metastatic and disseminated tumor cells by promoting antitumor immunity"1
ABSCOPAL EFFECT2
NON-IRRADIATED SIDE
Rt. tumor volume mm³
•
Control
■ Abs eff
* Absineff
800
400
0
IRRADIATED SIDE
After 18 days
NON-IRRADIATED SIDE
Abs eff and AbSineff groups separated based on the
tumor-specific efficacy of PDT and abscopal effect
800
8 12 16
Days post inoculation
400
16
Days post inoculation
IRRADIATED SIDE
Treated
Control
PROTECTIVE IMMUNITY
Pre-
Endpoint
treatment
https://inviongroup.com/videos-reports/
A 2023 PDT study published in Nature¹
•
Demonstrated abscopal effect in melanoma and pancreatic
cancer models by inducing T cell activation and antitumor
immunity through PD-1/PD-L1 blockade
Elicited the inhibition of tumour growth
Improved abscopal effect by enhancing T cell infiltration and
inhibiting PD-1/PD-L1 interactions
"Substantial regression in tumour size observed at both right
(irradiated) and left (non-irradiated) site"¹
•
•
Triple Negative Breast Cancer (TNBC) is a hard-to-treat
cancer resistant to most chemotherapies
Proof of Concept (POC) pilot showed complete regression of
TNBC in vivo following INV043 treatment
Tumour mass undetectable two weeks after initial treatment
and no scarring evident
No recurrence of disease, re-challenge with TNBC implant
could not re-establish new tumours, suggesting development
of protective immunity
1 Adapted from https://www.nature.com/articles/s41598-023-30256-0 #citeas, using chlorin e6 photosensitizer.
2Abscopal Effect: When the treatment not only shrinks the targeted tumour but also untreated tumours elsewhere in the body.
INVIONView entire presentation