Transforming For Our Future

• • Our Sustainability Value Proposition ENVIRONMENTAL STEWARDSHIP Accelerating transition to a cleaner and more diverse portfolio 1 Target carbon reductions from 2005 levels: 50% by 2030; 85% by 2040; net- zero by 20502 - - Target additional renewable resources: 2,400 MWs by 2030 and total of 4,700 MWs by 2040 Advance coal-fired energy center retirements; extend life of carbon-free nuclear energy center Preferred plan consistent with objective of the Paris Agreement to limit global temperature rise to 1.5 degrees Celsius Significant transmission investment supporting cleaner energy No cast or wrought iron pipes in natural gas system 1 Based on Ameren Missouri 2020 IRP. Expect to file an update to the IRP in June 2022. 2 Includes Scope 1 emissions as described in Ameren's 2021 Climate Report. • • • GOVERNANCE Diverse BOD focused on strong oversight 57% women or racially/ethnically diverse; among the most diverse in the industry; average tenure of ~6 years BOD and committee oversight aligned with ESG matters Mgmt-level Sustainability Executive Steering Committee Named Chief Sustainability and Diversity Officer and Chief Renewable Development Officer Executive compensation supports sustainable, LT performance 10% long-term incentive for clean energy transition - 5% short-term incentive for supplier and workforce diversity Among top ranked companies in CPA-Zicklin Index for Corp. Political Disclosure and Accountability First Quarter 2022 Earnings | May 6, 2022 • • SOCIAL IMPACT Ameren Delivered value to customers in 2021 while focused on safety Improved reliability: 12% better since 2013 Affordable rates: ~25% below Midwest average Customer satisfaction 23% better since 2013; Ameren Illinois ranked #1 in residential customer satisfaction among peers in the Midwest for 2021 Socially responsible and economically impactful ~$140M to support eligible customers and charities from 2019-2021 Supporting core value of DE&I - Ranked #1 by DiversityInc on Top Utilities list in 2022; in top 5 on utilities list since 2009; a top company for ESG -$900M in diverse supplier spend in 2021; 11% increase from 2020 $10M committed to non-profits focused on DE&I 2021-2025 SUSTAINABLE GROWTH Expect 6% to 8% EPS CAGR 2022-20261 • Expect 7% rate base CAGR 2021-20261 Constructive frameworks for investment in all jurisdictions • • Strong long-term infrastructure investment pipeline of $45+ billion 2022-20311 • Expect future dividend growth to be in line with long-term EPS growth expectations 1 Issued and effective as of Feb. 18, 2022 Earnings Conference Call. 11

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