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Investor Presentaiton

Entering a data-rich period supporting potentially first-in-class/best- in-class assets with significant commercial potential cendakimab Ph III: EoE SOTYKTU (deucravacitinib) Ph III: PSA Induction II CAMZYOS™ (mavacamten) Ph III: nHCM SOTYKTU (deucravacitinib) Ph II: Alopecia Areata (AA) cendakimab Ph III: EGE AR LDD Ph II: 2L+ mCRPC Breyanzi Ph II: RR MZL Reblozyl (luspatercept-aamt) for injection 25mg 75mg Ph II: TD & NTD A-Thal Reblozyl (luspatercept-aamt) for injection 25mg 75mg Ph III: 1L TD MF anti-CCR8 Reblozyl (luspatercept-aamt) for injection 25mg 75mg Ph III: 1L NTD MDS Ph I: Solid Tumors Ph I: Solid Tumors CTLA4 NFPB Ph II: Solid Tumors 2024 - 2025 farletuzumab ecteribulin Ph II: NSCLC mezigdomide Ph III: 2L+ MM Vd combo LPA, Antagonist Ph III: IPF GPRC5D CAR T Ph II: RRMM DGK Inhibitor alnuctamab Ph III: 2-4L MM SOTYKTU (deucravacitinib) Ph III: PSA - Induction I MYK-224 Ph II: HFPEF BCL6 LDD Ph I: Lymphoma milvexian Phase III: SSP mezigdomide Ph III: 2L+ MM Kd combo BET inhib 158 Ph II: 1L MF farletuzumab ecteribulin Ph II: Ovarian ZEPOSIA. (ozanimod) Ph III: Moderate to severe CD - Induction II Opdualag Ph II: 1L Stage IV NSCLC CD19 NEX T Ph I: Severe refractory SLE Opdualag Ph II: 1L HCC Opdualag Ph I/II: 2L+ HCC (Post TKI) Opdualag Ph III: 2L/3L+ MSS MCRC Legend: Oncology Hematology Immunology 1. Japan or Asia study only 2. Confirmatory trial ll Bristol Myers Squibb" Note: excludes assets pending IND approval: HbF Inducer, BCMA x GPRC5D, CD19 NEXT in MS, & TYK2i-CNS Timeline represents data readouts or key data to inform clinical development (timeline not to scale) SOTYKTU (deucravacitinib) Ph III: Moderate to severe SLE Induction I SOTYKTU (deucravacitinib) Ph III: Moderate to severe SLE - Induction II TIGIT Bispecific Ph I: Solid Tumors iberdomide Ph III: 2L+ MM Breyanzi Ph III: RR FL (2L high risk)² Abecma decabrogene vicleucel) Ph III: 1L MM golcadomide Ph III: 1L LBCL once daily milvexian Ph III: ACS ONUREG (azacitidine) 2026 - 2030 Opdualag elF2B Activator Phase II: ALS Ph III: Adj. Melanoma Phase II/III: Low-or Int. Risk MDS ZEPOSIA (ozanimod) Ph III: Moderate to severe CD - Maintenance ZEPOSIA (ozanimod) Ph III: Moderate to severe CD Induction I Cardiovascular Neuroscience SOTYKTU (deucravacitinib) Ph III: SjS LPA1 Antagonist Ph III: PPF milvexian Ph III: AF anti-MTBR-Tau Ph II: Alzheimer's Disease iberdomide Ph III: NDMM Transplant Maintenance Not for Product Promotional Use 13
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