Fourth-Quarter and Full-Year 2019 Orphan and Rheumatology Segment Results slide image

Fourth-Quarter and Full-Year 2019 Orphan and Rheumatology Segment Results

Fourth-Quarter and Full-Year 2019 Orphan and Rheumatology Segment Results Driven by Strong KRYSTEXXA Growth ($M) KRYSTEXXAⓇ RAVICTIⓇ(1) PROCYSBIⓇ ACTIMMUNE® RAYOS® BUPHENYLⓇ(1) QUINSAIR™ LODOTRA®(1) Orphan and rheumatology segment net sales Q4 2019 Q4 2018 % Change FY 2019 FY 2018 % Change $110.7 $83.3 33 $342.4 $258.9 32 32 68.5 60.2 14 228.8 226.6 1 40.8 40.1 2 161.9 154.9 5 28.4 27.5 3 107.3 105.6 2 19.5 19.8 78.6 61.1 29 1.6 6.4 (75) 9.8 21.8 (55) 0.3 0.2 68 0.8 0.5 62 0.1 NM 2.1 NM $269.8 $237.6 14 $929.6 $831.5 12 Orphan and rheumatology segment operating income $95.4 $84.8 13 $306.3 $290.0 6 NM: Not meaningful. (1) Beginning in 2019, the Company no longer recognizes revenue from RAVICTI and AMMONAPS sales outside of North America and Japan, nor from sales of LODOTRA. On Dec. 28, 2018, the Company divested the rights to RAVICTI and AMMONAPS outside of North America and Japan. AMMONAPS is known as BUPHENYL in the United States. In addition, effective Jan. 1, 2019, the Company transferred the rights to LODOTRA to Vectura Group plc. LODOTRA is known as RAYOS in the United States. HORIZON 41
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