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Novartis New Organizational Model

Novartis has transformed into a focused medicines company, and delivered consistent performance Our strategy Focused medicines company powered by technology leadership in R&D, world-class commercialization, global access and data science Portfolio simplification in parallel Delivered strong performance & returned capital to shareholders Exit of Animal Health, Vaccines, Consumer Health Alcon spin-off Sale of Roche stake, returning majority of proceeds to shareholders through a buyback Sandoz strategic review USD 31bn in M&A / BD&L since 2018 strengthening Innovative Medicines (IM) portfolio Consistent IM top-line growth: 7% sales CAGR from 2018-2021 Consistent IM bottom-line delivery: 13% Core Oplnc CAGR and 4ppts margin improvement since 2018 Innovation capability expansion; built strengths in cell & gene, RNAi, radioligand therapy USD 36bn in share buybacks and dividends from 2018-2021 Source: Novartis Annual Report. Constant currencies (cc) and core results are non-IFRS measures. An explanation of our non-IFRS measures can be found in our Condensed Financial Report for Q4 and FY 2021, published February 2, 2022. 4 NOVARTIS NEW ORGANIZATIONAL MODEL | APRIL 04, 2022 | NOVARTIS INVESTOR PRESENTATION NOVARTIS | Reimagining Medicine
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