ReCell Placement and Medical Procedure Overview

Competition Procedure Skin graft Advantages • Standard of care • Specific graft procedure inexpensive Rapid procedure Disadvantages • Scarring, cosmetic issues, skin "quality" • Large, painful donor site • Infection, rejection • Extended hospitalization • Repeated operations Cultured epithelia (auto or allo) • Large coverage • Small donor site • Low infection • Expensive •2-6 weeks to grow • Allograph high rejection rate • Fragile ⚫ Cosmetic issues (skin matching, scarring) • Expensive • Fragile • Not skin matched: scarring • Extended hospitalization with interim wound coverage . Multiple procedures • Require specialised lab facilities ⚫ cost of immunosuppressive treatment Multiple procedures ⚫ "Not-ready-for-prime-time" Artificial skin Dermal matrixes • Large coverage • No donor site • Low infection/reject • Requires combination of above •Provide rapid coverage • Useful in severe, deep wounds Expensive • Extended hospitalization with interim wound coverage Multiple procedures Requires 'skin' of some sort ReCell Spray-On Skin • Rapid • Low cost, decrease hospitalization • Minimize donor site • Minimal scar • Low infection/reject ⚫ No lab requirements • Can be used in combination with other techniques • Requires paradigm change 29 medical avitä

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