Investor Presentaiton slide image

Investor Presentaiton

Laboratory testing T. pallidum Total Antibody Screen Syphilis RPR TPPA screen Negative n/a n/a Reactive Reactive n/a Reactive Non-Reactive¹ RPR Reactive² Non-Reactive Reactive Non-Reactive Non-Reactive Reactive Non-Reactive Interpretation No serologic evidence of past or current syphilis infection. In the setting of recent exposure, or signs/symptoms of primary syphilis, repeat testing in 2 to 4 weeks. Consistent with syphilis infection. Clinical manifestations and treatment history is required to refine interpretation: i) Infectious syphilis (primary, secondary or early latent) ii) Late latent syphilis iii) Tertiary syphilis iv) Treated syphilis with persistent reactive RPR No serologic evidence of past or current syphilis infection. Screening test is most likely falsely reactive. In the setting of recent exposure, or signs/symptoms of primary syphilis, repeat testing in 2 to 4 weeks. Indeterminate Syphilis serology inconclusive. T. pallidum particle agglutination (TPPA) Reactive Non-Reactive Reactive (or Repeat Reactive) Non-Reactive³ Indeterminate Reactive5 (or Repeat Reactive) Recommend repeat testing in 2 to 4 weeks. If results remain inconclusive upon repeat testing, this may represent falsely reactive serology or distant prior infection (treated or untreated). Consistent with syphilis infection. Clinical manifestations and treatment history is required to refine interpretation: i) Primary syphilis before RPR seroconversion ii) Secondary syphilis with RPR prozone effect (notify lab if suspected) iii) Late latent syphilis after RPR seroreversion iv) Treated syphilis Note: These results are also consistent with non-syphilitic treponematosis (bejel, yaws or pinta)
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