Investor Presentaiton
Laboratory testing
T. pallidum Total
Antibody Screen
Syphilis
RPR
TPPA
screen
Negative
n/a
n/a
Reactive
Reactive
n/a
Reactive
Non-Reactive¹
RPR
Reactive²
Non-Reactive
Reactive
Non-Reactive
Non-Reactive
Reactive
Non-Reactive
Interpretation
No serologic evidence of past or current syphilis infection.
In the setting of recent exposure, or signs/symptoms of primary syphilis,
repeat testing in 2 to 4 weeks.
Consistent with syphilis infection.
Clinical manifestations and treatment history is required to refine
interpretation:
i) Infectious syphilis (primary, secondary or early latent)
ii) Late latent syphilis
iii) Tertiary syphilis
iv) Treated syphilis with persistent reactive RPR
No serologic evidence of past or current syphilis infection.
Screening test is most likely falsely reactive.
In the setting of recent exposure, or signs/symptoms of primary syphilis,
repeat testing in 2 to 4 weeks.
Indeterminate Syphilis serology inconclusive.
T. pallidum particle
agglutination (TPPA)
Reactive
Non-Reactive
Reactive (or
Repeat
Reactive)
Non-Reactive³
Indeterminate
Reactive5
(or Repeat Reactive)
Recommend repeat testing in 2 to 4 weeks.
If results remain inconclusive upon repeat testing, this may represent falsely
reactive serology or distant prior infection (treated or untreated).
Consistent with syphilis infection.
Clinical manifestations and treatment history is required to refine
interpretation:
i) Primary syphilis before RPR seroconversion
ii) Secondary syphilis with RPR prozone effect (notify lab if suspected)
iii) Late latent syphilis after RPR seroreversion
iv) Treated syphilis
Note: These results are also consistent with non-syphilitic treponematosis
(bejel, yaws or pinta)View entire presentation