Investor Presentaiton

39 Oral Rigosertib produces levels in blood comparable to non-RDEB patients Dosing: 560 mg BID, 3 weeks on, one week off Concentration (ng/mL) 20000 18000 4 16000 14000 12000 10000 8000 6000 4000 2000 0 0 1 2 3 4 LO Time (h) -Cycle 1 --Cycle 2 -- Cycle 3 -*-Cycle 4 0 ONCONOVA THERAPEUTICS

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