Investor Presentation

50 Investor presentation First six months of 2022 Insulin market size and volume share of growth and market share Insulin market share and market size (DKK billion) Market growth A Market share Total 44% 268 3.8% +0.2% 50% Long- Acting 37% Fast- Acting 52% 92 69% Premix 17 34% Human 23 135 Novo Nordisk Competitors 40% 4.0% +0.3% 30% 5.0% 0.0% 20% Insulin volume: market growth and market share 10% 0.6% +2.3% 0% May 0.6% -1.3% 2019 -NN market share Source: IQVIA, May 2022, LHS graph - Value, RHS Graph - Volume, MAT, all countries; Share of growth not depicted due to too high numbers; NN: Novo Nordisk Novo NordiskⓇ 47% 8% 6% 4% 1% 2% 1% 0% May 2022 Market growth (right axis) NN growth (right axis)

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