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Investor Presentaiton

Serious Mental Illness (SMI) as a Dynamic, Emerging Process adapted from: McGorry P.D., et al., (Aug 2010): Clinical Staging. The Canadian Journal of Psychiatry, Vol 55, p. 489. Internalizing Major Depressive Episode Major Depressive Disorder Externalizin g Pervasive Psychological Disturbances Hypomanic Episode Schizo- phreniform Disorder Bipolar Psychosis Disorder Early Stage: mild, non-specific signs & symptoms 1 1 Mid-to-Late Stages: full disorders, moderate to severe symptoms Early-Stage Mild Signs and Symptoms: Internalizing Signs/Symptoms: Pervasive Psychological Disturbances: Externalizing Signs/Symptoms: Anxious, Depressive, Somatic Cognition, Perception, Affect, Language, Social relationships Impulsive, Disruptive conduct, Substance misuse/abuse
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