Q3 2021 Investor Relations Results slide image

Q3 2021 Investor Relations Results

Participants Company overview Pharmaceuticals Oncology Financial review Conclusion Appendix References Kisqali® grew +27% in Q3; MONALEESA-2 OS results reinforcing best-in-class profile Sales evolution USD bn, % cc Ex-US US +27% 232 KisqaliⓇ well positioned to become first-choice CDK4/6i ☐ Only CDK4/6i with positive OS results in 3 Ph3 trials ■ MONALEESA-2 unprecedented OS results in largest segment of aBC population Continued growth acceleration, with share gains ex-US ■ Ex-US: Market leader in pre-menopausal setting in EU4 and UK ■ US demand in pre-menopausal and post-menopausal picking up Moving forward with confidence in KisqaliⓇ and its unique profile ■ HARMONIA study to evaluate ribociclib vs. palbociclib in aggressive HER2-enriched intrinsic subtype of HR+/HER2- ABC ■ NATALEE study in eBC completed enrollment in Q2 2021; readout event-driven and expected end 2022 183 145 100 83 87 Q3 2020 Q3 2021 aBC advanced breast cancer eBC early breast cancer 34 Investor Relations | Q3 2021 Results NOVARTIS | Reimagining Medicine
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