2022 Highlights and ESG Progress

Q4 revenue growth supported by all regions and global businesses. Revenue breakdown Quarterly revenue drivers Q4'22 vs. Q3'22 Constant € mn 1.4bn 13,750 13,220 12,539 12,391 Revenue NII 1.2bn 10,400 9,808 9,178 8,904 NII Fees Trading gains 3,002 2,741 2,808 2,949 337 344 354 582 Fees Growth in Europe (+13%) and South America (+6%) Strong quarter in North America, after record NII in Q3 DCB activity offset by wholesale funding costs • Growth boosted by South America, mainly Brazil, and DCB Positive trends continued in: CIB +1%, WM&I (+3% including ceded fee income) and PagoNxt +18% 109 Other income • Q4 affected by DGF charges -234 Other 557 61 income Q1'21 Q2 Q3 Q4 Q1'22 Q2 Q3 Q4 Santander 17

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