Investor Presentaiton

Oncology Opdivo Opdualag TIGIT Bispecific DGK Inhibitor AR LDD AR LDD demonstrates on target AR degradation in tumor biopsy Patient Example Screening On Treatment AR protein is highly expressed in tumor cells 200 μm AR protein levels degraded with AR LDD after one cycle Ill Bristol Myers Squibb™ Source: Images from BMS internal database Not for Product Promotional Use 106

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