Matinas BioPharma Investor Presentation Deck

7 The Growing Threat of Invasive Fungal Infections (IFIS) Nature Reviews Microbiology 2022 Tackling the emerging threat of antifungal resistance to human health WIRED The Battle Against the Fungal Apocalypse Is Just Beginning HARYN CHENNA SCIENCE AUG 25, 2823 6:30 AM Fungal infections are rising worldwide and climate change may be to blame. Medicine isn't ready. WHO fungal priority pathogens list to guide research, development and public health action World Health Organization Wall Street Journal Deadly Fungal Infections Confound Doctors-'It's Going to Get Worse' https://www.wsj.com/articles/deadly-fungal-infection-candida-a Once a freak occurrence, fungi resistant to standard drugs now threaten millions of vulnerable Americans By Dominique Mosbergen Follow June 22, 2023 9:59 am ET Check for upclates Matthew C. Fisher, Ana Alastruey-Izquierdo, Judith Berman, Tihana Bicanic, Elaine M. Bignell, Paul Bowyer, Michael Bromley, Roger Brüggemann", Gary Garber, Oliver A. Cornely, Sarah. J. Gurr, Thomas S. Harrison, Ed Kuijper", Johanna Rhodes, Donald C. Sheppard, Adilia Warris ³. P. Lewis White Ⓡ¹, Jianping Xu", Bas Zwaan¹5 and Paul E. Verweij Abstract | Invasive fungal infections pose an important threat to public health and are an under-recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a period of profound global environmental change and expanding at-risk populations, human- infecting pathogenic fungi are evolving resistance to all licensed systemic antifungal drugs. In this Review, we highlight the main mechanisms of antifungal resistance and explore the similarities and differences between bacterial and fungal resistance to antimicrobial control. We discuss the research and innovation topics that are needed for risk reduction strategies aimed at minimizing the emergence of resistance in pathogenic fungi. These topics include links between the environment and One Health, surveillance, diagnostics, routes of transmission, novel therapeutics and methods to mitigate hotspots for fungal adaptation. We emphasize the global efforts required to steward our existing antifungal armamentarium, and to direct the research and development of future therapies and interventions. Scientific American Fungus Candida auris lurks in hospitals, where it infects patients with impaired immune systems. Credit: Juan Gaertner Science Source Deadly Fungi Are the Newest Emerging Microbe Threat All Over the World These pathogens already kill 1.6 million people every year, and we have few defenses against them By Maryn McKenna New York Times v York Times SUNDAY, APRIL 7, 2019 Jumal 2021 COPYRIGHT MATINAS BIOPHARMA O Cody w the made as the her 70s Showered underm Fungus Immune to Drugs Secretly Sweeps the Globe Mysterious Bug Adds Alarming Dimension to Dangers of Overusing Medicines By MATT RICHTEL and ANDREW JACOBS Last May, an elderly man was admitted to the Brooklyn branch of Mount Sinai Hospital for ab dominal surgery. A blood test re- vealed that he was infected with a newly discovered germ as deadly as it was mysterious. Doctors $6.00 2024 world's most intractable healt threats the rise of drug-resista infections. perts have warned that the ov For decades, public health e use of antibiotics was reducing effectiveness of drugs that h lengthered life spars by e BLIGHT FUNGI AND THE COMING FANDEMIC Emily Monosson Wall Street Journal Dangerous Fungi Are Spreading Across U.S. as Temperatures Rise SCIENCE Some fungi such as the type that causes Valley Fever might be adapting to endure more heat stress By Dominique Mosbergen Follow Feb. 1, 2023 10:08 am ET Save AA 408 NBC Nightly News DEADLY FUNGUS SPREADING IN U.S. Listen (5 min) NIGHTLY NEWS MATINAS BIOPHARMA

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