Evotec Investor Day Presentation Deck

Cohort CKD NS CKD Healthy donors Healthy donors CKD evotec NS PAGE 57 NURTORE National Unified Renal Translational Research Enterprise NURTO RE National Unified Renal Translational Research Enterprise Salford Royal NHS NHS Foundation Trust QUOD Quality in Organ Donation Not disclosed Not disclosed Not disclosed Worldwide largest PanOmics approach to CKD > 10.000 patients in Chronic Kidney Disease and growing Patients 3000 800 2500 1000 200 3000 100-200 Biopsies 450 450 200 1000 100+ 500 + tbd Other Samples Blood, serum, urine Blood, serum, urine DNA, serum n/a Biopsies, glomeruli, blood, serum, urine Blood Blood, serum, urine Comment Baseline recruitment completed; 1 year follow up ongoing Recruitment 65% completed Cohort completed Kidney & donor-matched liver and heart tissues Scalable; 100 HD samples in Q3 2020 Blood: baseline & 6-years follow up option for further follow up samples Remission vs relapse https://www.nurturebiobank.org/; NURTURE: National Unified Renal Translational Research Enterprise; https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/salford-kidney-study/; SKS: Salford Kidney Study (CRISIS); HD: Healthy Donor; NS: Nephrotic Syndrome; QUOD: https://quod.org.uk/ EVT Data Exclusivity 7 years 7 years 5 years 5-7 years 5 years TBD TBD

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