Investor Presentaiton

Investor presentation Full year 2018 Slide 74 OzempicⓇ approved in the USA and in the EU Profile OzempicⓇ label in the USA • Adjunct to diet and exercise to improve glycaemic control Two therapeutic dosages, 0.5 mg and 1 mg CV data from SUSTAIN 6 trial in OzempicⓇ EU label OzempicⓇ label VictozaⓇ label • Reduction in HbA1c VS comparators¹ Efficacy Conve- nience Safety Reduction in body weight vs comparators¹ Administered once-weekly To be launched in the OzempicⓇ pen Retinopathy wording similar to insulin labels Cardiovascular safety with number of MACE events in clinical section² 1 Statistically significant reduction compared to comparators: placebo, sitagliptin, exenatide extended- release and insulin glargine U100 (phase 3a SUSTAIN trial programme) 2 In SUSTAIN 6, there were 108 MACE events with OzempicⓇ compared to 146 events with placebo, equivalent to an event rate of 6.6% with Ozempic® and 8.9% with placebo MACE: Major adverse cardiovascular events changing diabetes Trial Patients Reference to CV results in indication MACE Kaplan-Meier SUSTAIN 6 LEADER 9,340 3,297 Included Included HR: 0.741 HR: 0.872 Included Included 195% confidence interval [0.58;0.95]. 295% confidence interval [0.78;0.97] CV: Cardiovascular; HR: Hazard ratio novo nordisk

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