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Investor Presentaiton

19 Commercial execution and innovation Diabetes care Insulin icodec, a basal insulin intended for once-weekly treatment, may reduce the disease burden for patients Bringing the strongest value proposition to market Insulin icodec phase 3 programme expected to complete during 2022 TIR: Time-in-range ONWARDS 1 970 people insulin-naïve, 78-week, vs insulin glargine U100 Reduction of disease burden with once-weekly treatment 520 people on basal, 26- ONWARDS 2 Tested for superior HbA₁ and TiR vs glargine and standard-of-care and week, vs insulin degludec 580 people insulin-naïve, 26-week, ONWARDS 3 similar safety profile of TresibaⓇ vs insulin degludec ONWARDS 4 App-based offering and connected smart pen to optimise titration and support compliance and data collection ONWARDS 5 ONWARDS 6 Reduced environmental footprint 580 people on both basal and bolus, 26-week, vs insulin degludec 1,100 people, insulin-naïve using app-based dosing recommendations, 52-week 580 people, type 1 diabetes using bolus insulin, 52-week, vs insulin degludec 2022 Novo NordiskⓇ CMD22 CAPITAL MARKETS DAY
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