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Reimagining Medicine

Company overview Financial review Conclusions Appendix References GROWTH KesimptaⓇ continues strong launch trajectory doubling sales vs. PY Kesimpta Sales evolution USD m, % cc Ex-US US US NBRx1 Rolling 4 weeks 350 300 +105% 250 489 116 200 150 239 100 373 204 60 50 0 Q2 2022 Q2 2023 Sept 2020 June 2023 Global sales US: Growing faster than market1,2 TRX +80% YTD vs. PY (market flat) NBRX +43% vs. PY (market +1%) B-cell NBRX share -54% of MS market Europe: Strong launch momentum³ >24k patients treated, thereof >1/3 naive patients Confident in future growth Significant room to grow About a third of patients with MS on B-Cell therapy 1,2 Compelling product profile 1 minute a month dosing from home/anywhere³; 5-year efficacy and safety data 5,6 See last page for references. TRX total prescriptions. NBRX-new to brand prescription. Constant currencies (cc), core results are non-IFRS measures; explanation can be found on page 48 of Condensed Interim Financial Report. 11 Investor Relations | Q2 2023 Results ✓ NOVARTIS | Reimagining Medicine
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