Guardant Health Investor Presentation
Digital Sequencing Platform: underlying technology
Guardant Digital Sequencing Biochemistry and Error Reduction
High-
Efficiency
Chemistry
Source: Odegaard et al. CCR, 2018.
MOLECULE RECOVERY EFFICIENCY
High-Efficiency Biochemistry
1.0-
2-3X conversion higher efficiency
0.9
than other methods
0.8-
Learning
Bioinformatics
Engine
0.7
0.6
0.5
0.4.
5
CFDNA INPUT (NG)
T
ERROR RATE, LOG10
1000X reduction in
sequencing error
rate
Learning Bioinformatics Engine
-3.5-
-4.0-
-4.5-
-5.0-
-5.5-
-6.0-
-6.5-
SE
PE
MOL
DS
Digital Sequencing unlocks signal from noise across all 4 classes of genomic alterations and MSI
100%
• 60 9000
10%
1%
0.1%
0.01%
Standard NGS
100%
00
000000
Guardant Digital Sequencing
10%
Noise lowered by >3 orders of magnitude
SNV
1%
0.1%
0.01%
8
GUARDANTView entire presentation