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Investor Presentaiton

SELECT TRIALS - IMLUNESTRANT Study Indication* Title Phase Patients Primary Outcome* ** Lilly Primary Completion Completion Breast NCT04975308 Neoplasms Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer (EMBER-3) 3 860 Progression Free Survival (PFS) in the Intent-to-Treat (IIT) Population Apr 2024 Aug 2027 NCT05514054 Breast Neoplasms A Study of Imlunestrant Versus Standard Endocrine Therapy in Participants With Early Breast Cancer (EMBER- 3 4) 6000 Invasive Disease-Free Survival (IDFS) Oct 2027 Mar 2032 * Molecule may have multiple indications ** Trial may have additional primary and other secondary outcomes Not for promotional use Source: clinicaltrials.gov, July 17, 2023 2023 Q2 EARNINGS 39
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