Investor Presentaiton

B cell ONENESS IL-6 in Severe Asthma (Neutrophil High) Severe Asthma with high neutrophils have been a large unmet need Dendritic Cells APC Th2 IL-4, 13 IL-4 Dendritic Cells APC Severe Neutrophilic Asthma affects IL6 FB704A Th17 Th1 5.5 million patients worldwide IL-5 IL-17A IFNY IgE Eosinophilic inflammation Eosinophilic asthma Eosinophil Neutrophil Neutrophilic inflammation Neutrophilic Asthma IL6 is a key cytokine to asthma (neutrophilic phenotype) Modified from Front Immunol. 2018;9:2718 Remain unmet medically Effective biologic treatment can create billion market potential | 23

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