Investor Presentation - First Nine Months of 2016

Investor presentation First nine months of 2016 Slide 88 Haemophilia: Location of bleedings and the consequences changing diabetes Head and neck Muscles Locations Gut Nose and gums Joints Joints Kidneys Joints Joints Consequences of bleedings Bleeding in the joint space causes a strong inflammatory reaction which predisposes to further bleeding Inadequate or delayed treatment of repeated joint bleeds results in a "target joint" ⚫ The joint is tense, swollen and extremely painful and the mobility is restricted • Eventually the cartilage erodes completely and permanent joint damage (arthropathy) occurs Treatment of arthropathy is orthopaedic surgery novo nordisk

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