Investor Presentaiton

Investor presentation First three months of 2017 Slide 34 UKPDS: Tight glycaemic control reduces risk of micro- and macrovascular complications Risk reduction by lowering HbA1c by 1%-point UKPDS 10 year follow-up: Legacy effect of tight glycaemic control Relative risk reduction of intensive vs. conventional treatment (%) Diabetes- related death Peripheral Myocardial Microvascular vascular infarction complications disease 0 SU/Insulin treated patients -10 Microvascular disease 1997 2007 25 24 Incidence risk (%) -14% -20 -21%* -30- -40 *p<0.0001 -50 Source: UKPDS, Stratton et al. BMJ 2000; vol. 321:405-12 changing diabetes® Diabetes-related death Myocardial infarction -37%* All-cause mortality -43%* 10 10 17 16 15 6 13 Statistically significant improvement Source: NEJM, vol. 359, Oct 2008 novo nordisk

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