Investor Presentaiton

Tissue Expanders ALLOX2 SUPPORTING HEALTH AND ECONOMIC OUTCOMES A seroma increases the risk of major infection in breast reconstruction patients • Clinically relevant infection in poor salvage rates occurred in 1/5 seroma patients (18.8%) 1 • • With current standard of care, 78% of infections require explantation¹ Re-operation costs can run upwards of +$20K² ADM (ACELLULAR DERMAL MATRIX) $6-12,000 per breast* BREAST TISSUE EXPANDER > $1,300 - 2,300 per breast OR/ANESTHESIA COSTS $17,500 2 hr procedure and 1-2 nights ICU stay** TOTAL ESTIMATED REOPERATION COST $25 - $32K Unilateral $32 - $46K Bilateral Allox2 clinically shown to improve expander salvage rates and clinical outcome³ 100% Surgeon Satisfaction Using Allox24 BREAST Sientra AlloX2 Short-Term Case Study, Surgical Pearls, and Roundtable Discussion In a clinical study with 40 primary reconstruction patients, the Allox2 was deemed successful in treating seromas and should be considered a tool for noninvasive treatment of common complications of tissue expander-based reconstruction sientra. 1 Jordan SW, Khavanin N, Kim JYS. Seroma in prosthetic breast reconstruction. Plast Reconstr Surg. 2016;137:1104-1116; 2 Macario A. What does one minute of operating room time cost? Journal of Clinical Anesthesia. 2010;22, 233-236; 3 Fairchild B, Ellsworth W, Selber JC, Bogue DP, Zavlin D, Nemir S, Checka CM, Clemens MW. Safety and Efficacy of Smooth Surface Tissue Expander Breast Reconstruction. Aesth Surg. Volume 40, Issue 1, January 2020, Pages 53-62, https://doi.org/10.1093/asi/siy 199.4 Zeidler K, Capizzi P, Pittman T. (2018). Sientra AlloX2 Short Term Case Study, Surgical Pearls & Roundtable Discussion. Manuscript submitted for publication. 11

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