Certara Investor Day Presentation Deck

Ibrutinib model predicted untested scenarios Ketoconazole Cmax (observed) AUC Ketoconazole Cmax (simulated) AUC Erythromycin Cmax AUC Diltiazem Fluvoxamine Efavirenz Cmax AUC Cmax AUC Cmax AUC Rifampin Cmax (simulated) AUC Cmax Rifampin (observed) AUC 0.01 I 0.07 0.08 0.06 0.08 Drug-Drug Interaction Scenarios Observed DDI Verification Prediction 0.1 I 0.38 0.38 2.2 2.0 1.0 Ratio with 95% confidence interval 7.5 86 5.0 5.5 10.0 31 27 21 30 100.0 The Simcyp Simulator accurately predicted observed drug interactions and was used to study new scenarios, avoiding several DDI studies. 48 CERTARA

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