Vaxcyte Corporate Presentation

VAX-24 Employs Carrier-Sparing Conjugates XpressCF Enables Precise Conjugation to Enhance Potency of Standard Protein Carrier 19 19 Precise, Site-Specific Conjugation Sites on Proprietary eCRM® Protein Carrier Illustrative nnAA Conjugation Anchors (red) 500 Avoid T-cell Epitope Regions (pink) о Final VAX-24 Conjugates in Customary Matrix Form eCRM: Enhanced Potency Potential • Avoids masking sites on CRM 197 carrier responsible for T-cell help • Optimized sites for conjugation using copper-free click chemistry · More consistent antigenic presentation Carrier-Sparing Conjugates • • Less protein carrier / conjugate may allow addition of more serotypes while minimizing carrier suppression and maintaining immunogenicity VAX-24 and VAX-XP conjugates form standard PCV interstrand crosslinked matrices - Perceived as foreign by the host Allows use of standard critical quality attribute & serological assays

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