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Investor Presentation

8 Investor presentation First six months of 2022 GLP-1 class expansion continues in the US as new prescriptions have accelerated in the second quarter of 2022 US GLP-1 weekly NBRx prescriptions Weekly NBRX scripts ('000) 50 50 40 40 30 20 10 0 July 2020 OzempicⓇ TRX share 80% 60% 48.7% 40% 20% 0% July 2022 July 2020 RybelsusⓇ - VictozaⓇ NN GLP-1 dulaglutide Novo NordiskⓇ US GLP-1 TRX market share Total GLP-1 Class growth >35% scripts ('000) 4,000 ⚫tirzepatide 56.4% 3,000 40.7% 2,000 40.6% 7.9% 1,000 7.7% 1.1% 0 July 2022 Total monthly GLP-1 scripts Source: IQVIA Xponent, Weekly (ending 15 July 2022) Each data points represents a rolling four-week average. Total GLP-1 scripts constitute all prescriptions of GLP-1 medications in the market and have the full month of July as latest available data point NBRX: New-to-brand prescriptions; TRx: Total prescriptions; NN: Novo Nordisk; Scripts: Prescriptions Note: Class growth calculated as Q2 2022 vs Q2 2021
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