2022 Highlights and ESG Progress

Efficiency 32.4% +2.6pp Brazil Selective volume growth, mainly secured and corporates Profit remained high in a difficult scenario given inflation and higher interest rates In Q4, NII and fees increased. Profit impacted by higher costs (labour agreement and activity) and LLPs (lower without one-off) Loans €92bn +8% Deposits €76bn +4% Mutual Funds €45bn 0% COR ROTE¹ 4.79% +106bps 24.9% -2.8pp Chile Focus on Getnet and Santander Life, boosting banking penetration. #1 in NPS Profit up YoY due to higher revenue (fees and trading gains), cost control and lower tax burden NII affected by the negative sensitivity to interest rate hikes Loans €45bn +8% Deposits €29bn -8% Mutual Funds €9bn +3% Efficiency COR 40.1% +1.7pp 0.93% +8bps ROTE¹ 28.7% +3.8pp P&L* NII Q4'22 % Q3'22 2,229 0.8 2022 8,901 % 2021 % 2021² P&L* Q4'22 % Q3'22 2022 % 2021 % 2021² -3.7 13.1 NII 332 -17.3 1,772 -8.7 -10.6 Net fee income 884 11.0 3,296 2.8 20.8 Net fee income 127 6.2 468 21.3 18.8 Total revenue 3,240 0.6 12,910 1.0 18.7 Total revenue 515 -10.7 2,449 1.9 -0.3 Operating expenses -1,171 12.6 -4,180 9.9 29.2 Operating expenses -244 -1.7 -981 6.4 4.1 Net operating income 2,069 -5.1 8,730 -2.8 14.3 LLPs -1,252 10.6 -4,417 38.4 62.7 Net operating income LLPs 271 -17.5 1,468 -0.9 -3.0 -108 26.5 -399 19.5 16.9 Underlying att. profit 517 -20.6 2,544 -6.7 9.7 Underlying att. profit 126 -21.0 677 8.8 6.5 (*) € mn and % change in constant euros. (*) € mn and % change in constant euros. Santander Note: 2022 data and YoY changes (loans, deposits and mutual funds in constant euros). (1) Adjusted RoTES: adjusted based on Group's deployed capital calculated as contribution of RWAs at 12%. Using tangible equity, ROTE is 19.2% for Brazil and 19.5% for Chile. (2) % change in current euros. 42

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