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Obesity Petrelintide Petrelintide significantly reduced fat mass Unpublished while preserving lean mass in DIO rats Change in body weight at Day 30 data Change in body composition at Day 30 Fat mass ZEAL& ZEALAND PHARMA Mean (SEM) change in body weight (%) 10 5 -5 -10 Vehicle * *** Liraglutide 5 nmol/kg BID *** Mean (SEM) change in fat mass (% of body weight) Mean (SEM) change in lean mass (% of body weight) 2 T 0 -2 -4 *** 2 Dry lean mass 0 N + *** -6 Petrelintide 2 nmol/kg Q2D Petrelintide 10 nmol/kg Q4D *p<0.05, ***p<0.001 vs vehicle. Source: Figures adapted from Data on file. BID=twice daily; DIO-diet-induced obese; Q2D=every 2 days; Q4D=every 4 days; SEM=standard error of the mean. H *** *** 14

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