Investor Presentation First Nine Months of 2022

118 Investor presentation First nine months of 2022 Insulin market size and volume market share in EMEA Insulin market share and market size (DKK billion) Total 49% Long- acting 41% Fast- 55% 12 acting 74% Premix 3 19 43% Human 3 Novo Nordisk Competitors Market growth A Market share 60% 37 2.3% +0.3% 4.1% +1.4% 40% Insulin volume: Market share EMEA 10% 48% 7% 4% 1% 3.8% -1.1% 20% -3.6% +1.4% 0% Aug 2019 NN market share -6.5% -0.5% Source: IQVIA, Aug 2022, LHS graph - Value, RHS Graph - Volume, MAT, Europe, Middle East & Africa, Share of growth not depicted due to too high numbers; NN: Novo Nordisk 1% 1% -2% Aug 2022 Market growth (right axis) -NN growth (right axis)

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