Investor Presentation - First Nine Months of 2016
Investor presentation
First nine months of 2016
Slide 52
GLP-1 effect dependent on level of blood glucose - which
reduces risk of hypoglycaemia
GLP-1 mechanism of action when blood
sugar levels increase
•
Increases insulin secretion in the pancreas
Reduces glucagon secretion in the liver
• Slows gastric emptying in the gut
.
Creates sense of satiety in the brain
Brain
GLP-1 lowers blood glucose in patients
with type 2 diabetes
Type 2 diabetes patients, no GLP-1
Type 2 diabetes patients, with GLP-1
Healthy controls receiving saline
Glucose
(mmol/L)
18
16
14
12
10
8
6
changing
diabetes
GLP-1
Liver
Gut
Pancreas
642O
Breakfast Lunch Snack
22.00
02.00
06.00
10.00
T
14.00
18.00
Time
Source: Rachman et al. Diabetologia 1997;40:205-11
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