Reimagining Medicine

Company overview Innovation: Pipeline overview Cardiovascular Financial review Immunology Cosentyx® - IL-17A inhibitor NCT04181762 SELUNE (CAIN457Q12301) Indication Lupus Nephritis Phase Phase 3 Patients 460 Primary Proportion of subjects achieving protocol-defined CRR Outcome Measures Arms Secukinumab 300 mg s.c. Intervention Placebo s.c. 2023 priorities Innovation: Clinical trials Neuroscience Oncology Cosentyx® - IL-17A inhibitor NCT04930094 GCAPTAIN (CAIN457R12301) Indication Phase Giant cell arteritis Phase 3 Appendix Abbreviations Other Patients 348 Primary Outcome Number of participants with sustained remission Measures Arms Intervention Patients with active lupus nephritis (ISN/RPS Class III or IV, with or without co-existing class V features) Target Patients Experimental: Secukinumab 300 mg Placebo Comparator: Placebo Patients with Giant Cell Arteritis (GCA) Primary 2025 Final 2026 Readout Milestone(s) Publication TBD Target Patients Readout Milestone(s) 2025 Publication TBD 69 Investor Relations | Q4 2022 Results NOVARTIS | Reimagining Medicine

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