Investor Presentaiton

Isolation Period after Administration of GT products for Viral Shedding/Cartagena (1) Vector Gene Targeted disease Medical Institution/ Administration Isolation Cartagena Method Period Approval Sponsor adenosine ADA- Hokkaido Univ. Bone marrow 3 days 2005 deaminase deficiency Hospital cells, ex vivo (ADA) HSV-TK and recurrent Tsukuba Univ. Lymphocytes, 3 days 2005 ALNGFR leukemia Hospital ex vivo Retro (acute /TAKARA BIO 3 days 2007 GVHD) Inc. MDR1 (multi-drug resistance 1) Breast Cancer Institute cancer Hospital of CD34 cells, ex vivo 10 days 2005 JFCR

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