Investor Presentaiton

Potential to improve coverage with Machine Learning Proof of concept achieved for H3 & H1 strains ML model robustly selects strains with greater breadth¹ ML-strains cover broader H1 Seasonal Influenza Space vs WHO strain² Antigenic space 2 Antigenic space 1 WHO strain ML Selection Breadth of coverage 52 Vaccines Investor Event sanofi 6B.1A.5a.2 8.00 6B.1A.5a.2 6B.1 4.00 0.00 WHO strain -4.00 6B.1A.5a.1 ML1 strain 6B.1A.1 -8.00 ML2 strain 6B.1A.5b 6B.1A 6B.1A.5a.1 6B.1A.5a.1 ML offers meaningful advances in strain selection process as demonstrated now also for H1 strains 1. Theoretical representation for illustrative purposes 2. Log2 fold change of mNT titers compared to WHO strain. Color boxes represent different H1 sequence clades from Nexstrain

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