Immix Biopharma Investor Presentation Deck

Nature of AL Amyloidosis Diseased AL Amyloidosis Plasma Cells Express BCMA Target On Cell Surface AL Amyloidosis Is Caused By Malignant Plasma Calls That Produce Misfolded Amyloid Protein ... Bone marrow 1) PLASMA CELL/ MATURE B CELL CLONE Circulation 2) NATIVE LIGHT CHAINS Misfolding/ oligomerization 3) AMYLOID FIBRILS 4) CELL DAMAGE Target tissues/endothelium Which Damages Primary Organs Including: Heart, Liver, Kidney Heart • Heart failure with preserved ejection fraction • Thickened ventricular walls and low voltages on electrocardiography • Dysponea at rest or exertion, fatigue • Hypotension or syncope • Peripheral oedema Source: Merlini, G., et al. Nat Rev Dis Primers. Oct 2018, Front. Cardiovasc. Med., Dec 2022, Hemato 2022, 3(1), 47-62; https://doi.org/10.3390/hemato3010005 ●●● IMMIX S BIOPHARMA Liver • Increased alkaline phosphatase • Hepatomegaly Kidney • Nephrotic range proteinuria • Renal failure • Peripheral oedema 19

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