Kymera Investor Day Presentation Deck

DNA Damage p53 Stressors Hypoxia # MDM2 is the E3 Ligase that Modulates P53, the Largest Tumor Suppressor p53 Oncogenes MDM2 p53 ub ub ub MDM2 Tumor Suppression KYMERA ©2021 KYMERA THERAPEUTICS, INC. Other p53 Degradation p53 Targets Feedback Loop Cell Cycle Arrest (p21, Ptprv) Apoptosis (Noxa, Bax, Puma) ● Cancer Genetics p53 is NOT mutated in almost 50% of tumors • MDM2 overexpression and amplification can ● inactivate p53 ● Large opportunity in wide variety of cancers Dependency of p53WT cells on MDM2 MDM2 CRISPR Sensitivity Score 0.6 0.4 0.2 0 -0.2 -0.4 -0.6 -0.8 -1 -1.2 -1.4 -1.6 -1.8 -2 -2.2 KYMERA R&D DAY - December 16th, 2021 p53MUT p53WT Graph generated with data obtained from DepMap.org Cell Line PAGE 76

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