2022 Highlights and ESG Progress

Spain Increased service quality reflected in customer and volumes growth, mainly in mortgages, consumer, CIB and deposits ⚫ Profit x2.5 vs. 2021 on the back of 9% higher NII, good cost control and 31bps CoR improvement . . UK Strong net mortgage lending (£9.8bn in 2022) NOI up 22% YoY supported by NII and efficiency gains Higher LLPs due to macro update vs. releases in 2021. Q4 profit impacted by the Bank Levy charge and the settlement agreed with the FCA (€127mn) Loans Deposits Mutual Funds Loans €250bn +2% €335bn +15% €72bn -10% €245bn +4% Deposits €222bn +2% Mutual Funds €7bn -17% Efficiency COR ROTE¹ Efficiency COR ROTE¹ 48.6% -3.7pp 0.61% -31bps 9.2% +5.4pp 49.6% -4.3pp 0.12% +21bps 15.4% -2.6pp P&L* Q4'22 % Q3'22 2022 % 2021 P&L* Q4'22 % Q3'22 2022 % 2021 % 2021² NII 1,405 25.5 4,539 9.0 NII 1,297 3.2 4,992 13.0 13.9 Net fee income 646 -7.3 2,818 1.0 Net fee income 95 3.4 390 -10.8 -10.1 Total revenue 2,175 2.5 8,233 6.3 Total revenue 1,388 0.9 5,418 11.6 12.5 Operating expenses -1,057 6.0 -3,998 -1.3 Operating expenses -677 4.3 -2,685 2.8 3.6 Net operating income 1,118 -0.6 4,236 14.6 Net operating income 710 -2.2 2,733 21.9 22.9 LLPs -390 -7.5 -1,618 -30.3 LLPs -82 -23.8 -316 Underlying att. profit 456 1.0 1,560 148.9 Underlying att. profit 257 -34.6 1,395 -10.0 -9.2 (*) € mn and % change. (*) € mn and % change in constant euros. Santander Note: 2022 data and YoY changes (loans, deposits and mutual funds in constant euros). (1) Adjusted RoTES: adjusted based on Group's deployed capital calculated as contribution of RWAs at 12%. Using tangible equity, ROTE is 7.9% for Spain and 10.7% for the UK. (2) % change in current euros. 37

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