BenevolentAl Therapeutics Pipeline and Triage
Data Preparation
Biological mechanism selection expands nuance and
data coverage, even for rare diseases
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Disease/Endotype
Mechanism
/ Pathway
Expert exploration
Tissue/
Cell Type
Recommendation
algorithms
Response to Insulin
Example analysis from Benevolent Platform™:
Pulmonary Arterial Hypertension
Associated with 32k scientific articles and
33k unique relationships from databases,
ontologies, genetic data, etc.
Mechanism Expansion
Endothelial Cell
Proliferation
Mechanism X
Relevance
Novelty
Specificity
Smooth muscle cell proliferation: 14k publications 6.9k relationships
Estrogen metabolism: 3.8k publications 2.4k relationships
Vasoconstriction: 107k publications 26k relationships
Asking the biological question
Biological process curation expands
data coverage and reveals novel
associations. Relationships from
similar biology can be leveraged in
predictive models.
Algorithms recommend important
aspects of biology in the context of a
disease. Metrics are computed to
evaluate mechanism relevance,
novelty, and specificity.
Scientists select concepts to form the
biological question they wish to ask at
the target inference stage.
Biologists and data scientists collaborate to guide data buildout predictions
Benevolent 17
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