Fourth-Quarter and Full-Year 2019 Orphan and Rheumatology Segment Results slide image

Fourth-Quarter and Full-Year 2019 Orphan and Rheumatology Segment Results

We Employ a Holistic Approach to Maximize the Value of Our Medicines for Patients ||| མ་ We DEEPLY UNDERSTAND the medicine, the disease and the market dynamics, investing in clinical data to advance the science We develop the right COMMERCIAL STRATEGY, TEAM AND INFRASTRUCTURE to support our patients and drive uptake We develop the right CLINICAL STRATEGY to improve physician understanding and clinical conviction to benefit more patients and optimize growth • KRYSTEXXA exemplifies our industry-leading holistic approach; we are leveraging this expertise with TEPEZZA KRYSTEXXA was an underperforming and undervalued asset at acquisition in January 2016 • We transformed its growth trajectory through strong commercial execution, quintupling annual net sales in 4 years • We are driving continued growth opportunities for KRYSTEXXA; projecting peak U.S. annual net sales of >$1B(1) • We are further maximizing KRYSTEXXA through our immunomodulation clinical strategy so more patients can benefit (1) Horizon estimate. HORIZON 8
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