Reimagining Medicine
Company overview
Innovation: Pipeline overview
Cardiovascular
Financial review
Immunology
Piqray® - PI3K-alpha inhibitor
NCT04729387 EPIK-O (CBYL719K12301)
Indication
Ovarian Cancer
Phase 3
2023 priorities
Innovation: Clinical trials
Neuroscience
Phase
Patients
358
Primary
Outcome
Measures
Arms
Intervention
Target
Patients
Progression Free Survival (PFS) based on Blinded Independent Review
Committee (BIRC) assessment using RECIST 1.1 criteria
Arm 1 Experimental: Alpelisib+olaparib: Alpelisib 200 mg orally once daily and
olaparib 200 mg orally twice daily on a continuous dosing schedule
Arm 2 Active Comparator: Paclitaxel or PLD. Investigator's choice of one of 2
single agent cytotoxic chemotherapies: Paclitaxel 80 mg/m2 intravenously
weekly or Pegylated liposomal Doxorubicin (PLD) 40-50 mg/m2 (physician
discretion) intravenously every 28 days.
Patients with platinum resistant or refractory high-grade serous ovarian cancer,
with no germline BRCA mutation detected
Readout
Milestone(s)
2023
Publication
TBD
89 Investor Relations | Q4 2022 Results
Oncology
Appendix
Abbreviations
Other
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