Half-Year 2022 Financial and Clinical Trials Update

Exchange rate impact on sales growth HY 2022: negative impact of JPY and EUR, positive impact of USD Development of average exchange rates versus prior year period CHF / USD CHF/EUR 2.2% 4.0% -4.9% -5.7% CHF/JPY -6.9% -8.9% Difference in CHF / CER -1.0% -0.2% growth Sales growth 2022 vs. 2021 11.2% 10.2% 5.4% 5.2% CER growth CHF growth Q1 HY YTD Sep FY CER = Constant Exchange Rates (avg full year 2021) Roche 202

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