Q4 2021 Results

Participants Company overview Pharmaceuticals Oncology Financial review Conclusion Appendix Financial performance Innovation: Pipeline overview Innovation: Clinical trials CRM IHD Neuroscience Ophthalmology Respiratory & Allergy Oncology: Solid Tumors Hematology Biosimilars Global Health Abbreviations alpelisib - PI3K-alpha inhibitor Study Indication Phase Patients Primary Outcome Measures Arms Intervention Target Patients Read-out Milestone(s) Publication NCT04589650 EPIK-P2 (CBYL719F12201) PIK3CA-related overgrowth spectrum Phase 2 150 Proportion of participants with a response at Week 24 Arm 1: alpelisib vs. Arm 2: placebo during the 16 first weeks, for each cohort (adult, pediatric), with placebo patients switching to alpelisib thereafter. Pediatric and adult participants with PIK3CA-related overgrowth spectrum (PROS) Primary Analysis: 2023 NA 114 Investor Relations | Q4 2021 Results NOVARTIS | Reimagining Medicine

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