Fourth-Quarter and Full-Year 2019 Orphan and Rheumatology Segment Results

Horizon is Simplifying the Process for Patients, Physicians and Sites of Care Patient Journey Before TEPEZZA Primary Care Progressive Phase (inflammation, pain) Fibrotic Phase (permanent damage, disfigurement) Ophthalmologist Allergist or Optometrist Patient finally diagnosed with TED Severity increases Steroids up to 8 grams Steroids fail Surgeries Endocrinologist Optic nerve compromised Surgery Repeat Doctor Visits and Tests Before, During and After Diagnosis Endocrinologist Recognizes TED symptoms and refers to ophthalmologist "Watch and Wait" Approach Simplifying the Patient Journey Ophthalmologist / Oculoplastic Surgeon / Neuro-Ophthalmologist Confirms diagnosis and refers patient to site of care TEPEZZA Infused at Site of Care HORIZON 19

View entire presentation